The WV Collegiate Strategic Prevention Framework Partnerships for Success (C-SPF PFS) initiative’s overall goal is to prevent the onset and reduce the progression of substance misuse and its related problems among higher education students (ages 18 and older) in a 21-county area covering southern West Virginia. The federal grant was awarded by the Substance Abuse and Mental Health Services Administration (SAMHSA) to Marshall University’s Center of Excellence for Recovery. The five-year initiative began August 31, 2020.